Companies: 10,636     total market cap: £101.287 T
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SPDR S&P Biotech ETF
XBI
#283
ETF rank
£6.29 B
Marketcap
🇺🇸 US
Market
£93.39
Share price
1.13%
Change (1 day)
27.34%
Change (1 year)
🧬 Biotech ETFs
Categories

SPDR S&P Biotech ETF - Holdings

Etf holdings as of December 22, 2025

Number of holdings: 156

Full holdings list

Weight %NameTickerShares Held
1.44%AMICUS THERAPEUTICS INCFOLD8491337.000
1.44%MODERNA INCMRNA3450934.000
1.34%EXELIXIS INCEXEL2439301.000
1.34%ROIVANT SCIENCES LTDROIV4949688.000
1.32%VAXCYTE INCPCVX2303502.000
1.32%BIOMARIN PHARMACEUTICAL INCBMRN1865521.000
1.30%MADRIGAL PHARMACEUTICALS INCMDGL181327.000
1.30%HALOZYME THERAPEUTICS INCHALO1599091.000
1.30%CYTOKINETICS INCCYTK1660987.000
1.29%RHYTHM PHARMACEUTICALS INCRYTM956241.000
1.28%REGENERON PHARMACEUTICALSREGN137972.000
1.28%PRAXIS PRECISION MEDICINES IPRAX382941.000
1.27%PTC THERAPEUTICS INCPTCT1351992.000
1.27%TRAVERE THERAPEUTICS INCTVTX2914001.000
1.27%BRIDGEBIO PHARMA INCBBIO1377992.000
1.27%UNITED THERAPEUTICS CORPUTHR206639.000
1.27%INCYTE CORPINCY1052701.000
1.26%AMGEN INCAMGN317666.000
1.24%KRYSTAL BIOTECH INCKRYS417892.000
1.24%VERTEX PHARMACEUTICALS INCVRTX225303.000
1.24%REVOLUTION MEDICINES INCRVMD1286390.000
1.24%IONIS PHARMACEUTICALS INCIONS1274053.000
1.22%GILEAD SCIENCES INCGILD825673.000
1.22%TG THERAPEUTICS INCTGTX3273920.000
1.22%MIRUM PHARMACEUTICALS INCMIRM1256223.000
1.21%ABBVIE INCABBV444885.000
1.21%AVIDITY BIOSCIENCES INCRNA1404141.000
1.21%NATERA INCNTRA429774.000
1.21%ALNYLAM PHARMACEUTICALS INCALNY247706.000
1.20%CIDARA THERAPEUTICS INCCDTX456195.000
1.20%EXACT SCIENCES CORPEXAS989411.000
1.20%CRISPR THERAPEUTICS AGCRSP1739578.000
1.20%SCHOLAR ROCK HOLDING CORPSRRK2223788.000
1.20%ARROWHEAD PHARMACEUTICALS INARWR1454662.000
1.20%ALKERMES PLCALKS3500443.000
1.19%ADMA BIOLOGICS INCADMA5014103.000
1.19%GRAIL INCGRAL1055365.000
1.19%CELCUITY INCCELC983839.000
1.18%BIOGEN INCBIIB564206.000
1.14%PROTAGONIST THERAPEUTICS INCPTGX1096290.000
1.14%ACADIA PHARMACEUTICALS INCACAD3414359.000
1.13%NEUROCRINE BIOSCIENCES INCNBIX643737.000
1.13%VIKING THERAPEUTICS INCVKTX2669390.000
1.12%ULTRAGENYX PHARMACEUTICAL INRARE2704846.000
1.11%INSMED INCINSM527674.000
1.07%SUMMIT THERAPEUTICS INCSMMT4956508.000
1.06%ARCUTIS BIOTHERAPEUTICS INCARQT2963337.000
1.02%KYMERA THERAPEUTICS INCKYMR1010113.000
1.01%BEAM THERAPEUTICS INCBEAM3045830.000
1.00%DYNE THERAPEUTICS INCDYN4027064.000
1.00%NUVALENT INC ANUVL791230.000
0.99%MINERALYS THERAPEUTICS INCMLYS2202948.000
0.97%SOLENO THERAPEUTICS INCSLNO1646402.000
0.95%VERA THERAPEUTICS INCVERA1478247.000
0.93%ARCELLX INCACLX1197184.000
0.92%IDEAYA BIOSCIENCES INCIDYA2176196.000
0.90%COGENT BIOSCIENCES INCCOGT1913208.000
0.89%APELLIS PHARMACEUTICALS INCAPLS2952871.000
0.87%RECURSION PHARMACEUTICALS ARXRX1.6598385E7
0.87%CG ONCOLOGY INCCGON1816935.000
0.85%SAREPTA THERAPEUTICS INCSRPT3345306.000
0.84%UNIQURE NVQURE2825871.000
0.82%TWIST BIOSCIENCE CORPTWST1957554.000
0.78%APOGEE THERAPEUTICS INCAPGE832944.000
0.77%CATALYST PHARMACEUTICALS INCCPRX2656180.000
0.76%SSI US GOV MONEY MARKET CLASS-6.39758106E7
0.76%VERACYTE INCVCYT1479601.000
0.75%IMMUNOVANT INCIMVT2267389.000
0.71%SYNDAX PHARMACEUTICALS INCSNDX2774588.000
0.68%DENALI THERAPEUTICS INCDNLI3282027.000
0.66%VIRIDIAN THERAPEUTICS INCVRDN1709017.000
0.64%CELLDEX THERAPEUTICS INCCLDX1956996.000
0.62%STOKE THERAPEUTICS INCSTOK1545199.000
0.60%BIOCRYST PHARMACEUTICALS INCBCRX6554161.000
0.59%DISC MEDICINE INCIRON618386.000
0.58%VERICEL CORPVCEL1295242.000
0.55%MANNKIND CORPMNKD7752035.000
0.55%AGIOS PHARMACEUTICALS INCAGIO1841560.000
0.52%DIANTHUS THERAPEUTICS INCDNTH991496.000
0.51%IMMUNOME INCIMNM1942718.000
0.50%JANUX THERAPEUTICS INCJANX3002386.000
0.47%BIOHAVEN LTDBHVN3585955.000
0.47%ARDELYX INCARDX6685435.000
0.46%NOVAVAX INCNVAX5644992.000
0.44%ARCUS BIOSCIENCES INCRCUS1592054.000
0.43%KURA ONCOLOGY INCKURA3210468.000
0.43%INTELLIA THERAPEUTICS INCNTLA3690773.000
0.42%DYNAVAX TECHNOLOGIES CORPDVAX3150973.000
0.41%TAYSHA GENE THERAPIES INCTSHA5907042.000
0.40%IOVANCE BIOTHERAPEUTICS INCIOVA1.210332E7
0.40%TANGO THERAPEUTICS INCTNGX3882256.000
0.39%RIGEL PHARMACEUTICALS INCRIGL738350.000
0.37%SPYRE THERAPEUTICS INCSYRE915040.000
0.37%CAREDX INCCDNA1561372.000
0.36%ANAPTYSBIO INCANAB604979.000
0.36%NURIX THERAPEUTICS INCNRIX1550726.000
0.35%PALVELLA THERAPEUTICS INCPVLA269530.000
0.35%KODIAK SCIENCES INCKOD1019725.000
0.34%RELAY THERAPEUTICS INCRLAY3319531.000
0.34%PRECIGEN INCPGEN6411013.000
0.32%XENCOR INCXNCR1674684.000
0.31%DAY ONE BIOPHARMACEUTICALS IDAWN2690008.000
0.30%ORIC PHARMACEUTICALS INCORIC3035575.000
0.29%REPLIMUNE GROUP INCREPL2414150.000
0.28%IMMUNITYBIO INCIBRX1.0405183E7
0.27%ARS PHARMACEUTICALS INCSPRY1979874.000
0.26%OLEMA PHARMACEUTICALS INCOLMA771115.000
0.26%SANA BIOTECHNOLOGY INCSANA4697100.000
0.25%ORUKA THERAPEUTICS INCORKA659319.000
0.25%RAPT THERAPEUTICS INCRAPT565110.000
0.24%GOSSAMER BIO INCGOSS5359125.000
0.24%UPSTREAM BIO INCUPB662819.000
0.23%EMERGENT BIOSOLUTIONS INCEBS1525111.000
0.23%CYTOMX THERAPEUTICS INCCTMX4687215.000
0.23%GERON CORPGERN1.4081163E7
0.22%BICARA THERAPEUTICS INCBCAX1024855.000
0.22%MONTE ROSA THERAPEUTICS INCGLUE1155405.000
0.22%LEXEO THERAPEUTICS INCLXEO1750265.000
0.21%SIONNA THERAPEUTICS INCSION423000.000
0.21%KALVISTA PHARMACEUTICALS INCKALV1123785.000
0.21%VERASTEM INCVSTM2215853.000
0.21%MYRIAD GENETICS INCMYGN2556671.000
0.18%REGENXBIO INCRGNX1014234.000
0.17%AKEBIA THERAPEUTICS INCAKBA8542795.000
0.17%INVIVYD INCIVVD4875330.000
0.17%ALTIMMUNE INCALT3354029.000
0.16%VIR BIOTECHNOLOGY INCVIR2291745.000
0.16%PROTHENA CORP PLCPRTA1414410.000
0.16%COMPASS THERAPEUTICS INCCMPX2599772.000
0.16%CORVUS PHARMACEUTICALS INCCRVS1708490.000
0.16%IMMUNEERING CORP CLASS AIMRX2239990.000
0.15%ABSCI CORPABSI3509190.000
0.15%INHIBRX BIOSCIENCES INCINBX147040.000
0.15%ANNEXON INCANNX2426805.000
0.15%4D MOLECULAR THERAPEUTICS INFDMT1429100.000
0.14%PRIME MEDICINE INCPRME3215975.000
0.13%ARRIVENT BIOPHARMA INCAVBP494708.000
0.13%KEROS THERAPEUTICS INCKROS518739.000
0.13%CULLINAN THERAPEUTICS INCCGEM1056616.000
0.12%ANAVEX LIFE SCIENCES CORPAVXL2677783.000
0.12%SAVARA INCSVRA1539530.000
0.11%ARBUTUS BIOPHARMA CORPABUS2005083.000
0.10%MIMEDX GROUP INCMDXG1187340.000
0.10%ERASCA INCERAS2244720.000
0.09%CONTRA METSERA INC-1530714.000
0.08%TYRA BIOSCIENCES INCTYRA264800.000
0.06%REZOLUTE INCRZLT2388231.000
0.04%IRONWOOD PHARMACEUTICALS INCIRWD1110900.000
0.02%CONTRA AKERO THERAPEUT-2033975.000
0.01%CONTRA INHIBRX INC-1645973.000
0.01%CONTRA MIRATI THERAPEU-1369552.000
0.01%CONTRA VERVE THERAPEUT-900273.000
0.00%CONTRA BLUEPRINT MEDIC-756469.000
0.00%OMNIAB INC 12.5 EARNOUT2200963D161959.000
0.00%OMNIAB INC 15.00 EARNOUT2200964D161959.000
-0.40%US DOLLAR--3.380173735E7

What is the market capitalization of a company?

The market capitalization sometimes referred as Marketcap, is the value of a publicly listed company.
In most cases it can be easily calculated by multiplying the share price with the amount of outstanding shares.

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