Companies: 10,638     total market cap: £101.443 T
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SPDR S&P Biotech ETF
XBI
#300
ETF rank
£5.79 B
Marketcap
🇺🇸 US
Market
£92.32
Share price
1.17%
Change (1 day)
18.76%
Change (1 year)
🧬 Biotech ETFs
Categories

SPDR S&P Biotech ETF - Holdings

Etf holdings as of December 3, 2025

Number of holdings: 135

Full holdings list

Weight %NameTickerShares Held
2.82%EXACT SCIENCES CORPEXAS2113297.000
2.65%REVOLUTION MEDICINES INCRVMD2585832.000
2.35%AVIDITY BIOSCIENCES INCRNA2494508.000
2.16%INSMED INCINSM793181.000
2.14%NATERA INCNTRA681746.000
2.14%BRIDGEBIO PHARMA INCBBIO2185543.000
2.06%MADRIGAL PHARMACEUTICALS INCMDGL269113.000
1.99%REGENERON PHARMACEUTICALSREGN208225.000
1.95%IONIS PHARMACEUTICALS INCIONS1808613.000
1.93%BIOGEN INCBIIB811661.000
1.89%AMGEN INCAMGN415622.000
1.85%UNITED THERAPEUTICS CORPUTHR291970.000
1.84%ROIVANT SCIENCES LTDROIV6736111.000
1.82%VERTEX PHARMACEUTICALS INCVRTX297891.000
1.80%INCYTE CORPINCY1341912.000
1.78%EXELIXIS INCEXEL3070400.000
1.66%ABBVIE INCABBV546909.000
1.65%GILEAD SCIENCES INCGILD1004307.000
1.64%NEUROCRINE BIOSCIENCES INCNBIX819627.000
1.64%CRISPR THERAPEUTICS AGCRSP2218717.000
1.58%MODERNA INCMRNA4761470.000
1.54%ALNYLAM PHARMACEUTICALS INCALNY246652.000
1.52%BIOMARIN PHARMACEUTICAL INCBMRN2123802.000
1.45%PTC THERAPEUTICS INCPTCT1452296.000
1.43%KRYSTAL BIOTECH INCKRYS498166.000
1.41%ARROWHEAD PHARMACEUTICALS INARWR1644732.000
1.40%AKERO THERAPEUTICS INCAKRO1938878.000
1.35%VAXCYTE INCPCVX2148508.000
1.34%VIKING THERAPEUTICS INCVKTX2867066.000
1.33%ADMA BIOLOGICS INCADMA5121280.000
1.33%PRAXIS PRECISION MEDICINES IPRAX540275.000
1.32%CIDARA THERAPEUTICS INCCDTX452572.000
1.30%HALOZYME THERAPEUTICS INCHALO1526993.000
1.27%TG THERAPEUTICS INCTGTX3049256.000
1.25%CYTOKINETICS INCCYTK1467321.000
1.22%PROTAGONIST THERAPEUTICS INCPTGX1075903.000
1.18%SUMMIT THERAPEUTICS INCSMMT4877150.000
1.17%SCHOLAR ROCK HOLDING CORPSRRK2033320.000
1.11%RHYTHM PHARMACEUTICALS INCRYTM801461.000
1.10%COGENT BIOSCIENCES INCCOGT2139689.000
1.08%ULTRAGENYX PHARMACEUTICAL INRARE2250132.000
1.01%ALKERMES PLCALKS2586898.000
0.97%NUVALENT INC ANUVL690012.000
0.96%ACADIA PHARMACEUTICALS INCACAD2804445.000
0.93%APOGEE THERAPEUTICS INCAPGE946127.000
0.89%SOLENO THERAPEUTICS INCSLNO1329743.000
0.86%VERACYTE INCVCYT1359080.000
0.85%KYMERA THERAPEUTICS INCKYMR982003.000
0.84%ARCUTIS BIOTHERAPEUTICS INCARQT2132458.000
0.82%GRAIL INCGRAL618394.000
0.81%DYNE THERAPEUTICS INCDYN3065870.000
0.72%SAREPTA THERAPEUTICS INCSRPT2518325.000
0.70%AMICUS THERAPEUTICS INCFOLD5445933.000
0.70%BEAM THERAPEUTICS INCBEAM1972163.000
0.69%CATALYST PHARMACEUTICALS INCCPRX2258189.000
0.68%VERA THERAPEUTICS INCVERA1258128.000
0.68%ARCELLX INCACLX707981.000
0.68%APELLIS PHARMACEUTICALS INCAPLS2420858.000
0.68%TWIST BIOSCIENCE CORPTWST1643086.000
0.66%RECURSION PHARMACEUTICALS ARXRX1.0787593E7
0.66%DENALI THERAPEUTICS INCDNLI2629837.000
0.65%DISC MEDICINE INCIRON536375.000
0.61%IDEAYA BIOSCIENCES INCIDYA1339482.000
0.60%TRAVERE THERAPEUTICS INCTVTX1297715.000
0.55%BIOCRYST PHARMACEUTICALS INCBCRX5310671.000
0.53%SYNDAX PHARMACEUTICALS INCSNDX2039285.000
0.51%CELLDEX THERAPEUTICS INCCLDX1401638.000
0.50%CG ONCOLOGY INCCGON886960.000
0.49%VERICEL CORPVCEL994815.000
0.45%MIRUM PHARMACEUTICALS INCMIRM476269.000
0.44%IMMUNOVANT INCIMVT1464683.000
0.40%VIRIDIAN THERAPEUTICS INCVRDN978664.000
0.40%UNIQURE NVQURE1191407.000
0.36%SPYRE THERAPEUTICS INCSYRE857990.000
0.36%AGIOS PHARMACEUTICALS INCAGIO981008.000
0.34%ARDELYX INCARDX4526364.000
0.34%DYNAVAX TECHNOLOGIES CORPDVAX2361215.000
0.34%ARCUS BIOSCIENCES INCRCUS1001474.000
0.34%NOVAVAX INCNVAX3717124.000
0.33%CAREDX INCCDNA1330098.000
0.32%IMMUNOME INCIMNM1243659.000
0.31%INTELLIA THERAPEUTICS INCNTLA2632747.000
0.29%NURIX THERAPEUTICS INCNRIX1329510.000
0.28%BIOHAVEN LTDBHVN2351959.000
0.26%TANGO THERAPEUTICS INCTNGX2089617.000
0.26%KURA ONCOLOGY INCKURA1628085.000
0.25%ANAPTYSBIO INCANAB432610.000
0.25%JANUX THERAPEUTICS INCJANX1095619.000
0.24%GERON CORPGERN1.4183521E7
0.24%MINERALYS THERAPEUTICS INCMLYS455692.000
0.23%XENCOR INCXNCR1004777.000
0.23%SANA BIOTECHNOLOGY INCSANA3853726.000
0.22%RELAY THERAPEUTICS INCRLAY2179550.000
0.22%MANNKIND CORPMNKD3011476.000
0.22%ARS PHARMACEUTICALS INCSPRY1760144.000
0.21%REPLIMUNE GROUP INCREPL1561467.000
0.21%STOKE THERAPEUTICS INCSTOK507998.000
0.21%EMERGENT BIOSOLUTIONS INCEBS1354797.000
0.20%TAYSHA GENE THERAPIES INCTSHA3447992.000
0.20%IOVANCE BIOTHERAPEUTICS INCIOVA6945158.000
0.20%DAY ONE BIOPHARMACEUTICALS IDAWN1834456.000
0.19%IMMUNITYBIO INCIBRX6506064.000
0.18%ORIC PHARMACEUTICALS INCORIC1230796.000
0.18%UPSTREAM BIO INCUPB496355.000
0.18%VERASTEM INCVSTM1320812.000
0.16%REGENXBIO INCRGNX946999.000
0.16%KALVISTA PHARMACEUTICALS INCKALV831055.000
0.16%MYRIAD GENETICS INCMYGN1621758.000
0.15%CELCUITY INCCELC115754.000
0.15%ALTIMMUNE INCALT2245968.000
0.15%KEROS THERAPEUTICS INCKROS633603.000
0.15%ARRIVENT BIOPHARMA INCAVBP494044.000
0.14%DIANTHUS THERAPEUTICS INCDNTH249207.000
0.14%AKEBIA THERAPEUTICS INCAKBA6929072.000
0.14%VIR BIOTECHNOLOGY INCVIR1650472.000
0.12%RIGEL PHARMACEUTICALS INCRIGL196713.000
0.10%CONTRA METSERA INC-1530714.000
0.09%REZOLUTE INCRZLT760443.000
0.09%ANAVEX LIFE SCIENCES CORPAVXL1559105.000
0.09%MIMEDX GROUP INCMDXG952505.000
0.08%CULLINAN THERAPEUTICS INCCGEM585678.000
0.07%ORUKA THERAPEUTICS INCORKA183857.000
0.07%COMPASS THERAPEUTICS INCCMPX1020350.000
0.07%PRECIGEN INCPGEN1477105.000
0.05%ARCTURUS THERAPEUTICS HOLDINARCT518472.000
0.04%ARBUTUS BIOPHARMA CORPABUS762448.000
0.02%ATYR PHARMA INCATYR2453296.000
0.02%SSI US GOV MONEY MARKET CLASS-1284256.790
0.01%CONTRA INHIBRX INC-1645973.000
0.01%CONTRA MIRATI THERAPEU-1369552.000
0.01%CONTRA VERVE THERAPEUT-900273.000
0.00%CONTRA BLUEPRINT MEDIC-756469.000
0.00%OMNIAB INC 12.5 EARNOUT2200963D161959.000
0.00%OMNIAB INC 15.00 EARNOUT2200964D161959.000
0.00%US DOLLAR--6108.940

What is the market capitalization of a company?

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In most cases it can be easily calculated by multiplying the share price with the amount of outstanding shares.

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