Heron Therapeutics
HRTX
#8889
Rank
$0.15 B
Marketcap
$0.82
Share price
3.07%
Change (1 day)
-57.97%
Change (1 year)

Heron Therapeutics - 10-Q quarterly report FY


Text size:
U.S. SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 10-Q


[X] Quarterly Report Under Section 13 or 15(d)
of the Securities Exchange Act of 1934

For the quarterly period ended March 31, 2006


[ ] Transition Report Pursuant to Section 13 or 15(d)
of the Securities Exchange Act of 1934

For the transition period from to
-------- --------

Commission file Number 0-16109


A.P. PHARMA, INC.
---------------------------------------------------
(Exact name of registrant as specified in its charter)


Delaware 94-2875566
- ------------------------------- ------------------------
(State or other jurisdiction of (IRS Employer
incorporation or organization) Identification No.)


123 Saginaw Drive, Redwood City, CA 94063
------------------------------------------
(Address of principal executive offices)

(650) 366-2626
----------------------------------------------------
(Registrant's telephone number, including area code)

Indicate by check mark whether the registrant (1) has filed all reports
required to be filed by Section 13 or 15 (d) of the Securities Exchange
Act of 1934 during the preceding 12 months (or for such shorter period
that the registrant was required to file such reports), and (2) has
been subject to such filing requirements for the past 90 days.
Yes X No
--- ---

Indicate by check mark whether the registrant is a large accelerated
filer, an accelerated filer, or a non-accelerated filer. See
definition of "accelerated filer and large accelerated filer" in
Rule 12b-2 of the Exchange Act.
Large accelerated filer [ ] Accelerated filer [ ]
---- ----
Non-accelerated filer [X ]
----

Indicate by check mark whether the registrant is a shell company (as
defined in Rule 12b-2 of the Exchange Act.)
Yes [ ] No [X ]
---- ----

At April 30, 2006, the number of outstanding shares of the Company's
common stock, par value $.01, was 25,330,941.
INDEX


PART I. FINANCIAL INFORMATION

ITEM 1. Financial Statements (unaudited):

Condensed Balance Sheets
March 31, 2006 and December 31, 2005

Condensed Statements of Operations
for the three months ended March 31, 2006 and 2005

Condensed Statements of Cash Flows
for the three months ended March 31, 2006 and 2005

Notes to Condensed Financial Statements

ITEM 2. Management's Discussion and Analysis of Financial
Condition and Results of Operations

ITEM 3. Quantitative and Qualitative Disclosure About Market Risk

ITEM 4. Controls and Procedures

PART II. OTHER INFORMATION

ITEM 1A. RISK FACTORS

ITEM 6. Exhibits

Signatures
PART I.    FINANCIAL INFORMATION
---------------------
ITEM 1. Financial Statements:
---------------------

A.P. PHARMA, INC.
- -----------------
CONDENSED BALANCE SHEETS
(in thousands)
- ------------------------
<TABLE>
<CAPTION>

March 31, December 31,
2006 2005
------------- ------------
(Unaudited) (Note 1)
<S> <C> <C>
ASSETS
Current assets:
Cash and cash equivalents $ 10,970 $ 790
Marketable securities 15,202 5,019
Accounts receivable, net 75 1,519
Prepaid expenses and other 365 320
------ ------

Total current assets 26,612 7,648

Property and equipment, net 1,095 1,164
Other long-term assets 139 157
------ ------
Total assets $ 27,846 $ 8,969
====== ======

LIABILITIES & STOCKHOLDERS' EQUITY
Current liabilities:
Accounts payable $ 388 $ 614
Accrued clinical trial expenses 820 892
Accrued disposition costs 245 248
Other accrued expenses 765 1,012

------ ------
Total current liabilities 2,218 2,766
------ ------

Stockholders' equity:
Common stock 99,404 99,248
Accumulated deficit (73,731) (93,029)
Accumulated other comprehensive
loss (45) (16)
------ ------
Total stockholders' equity 25,628 6,203
------ ------
Total liabilities and stockholders'
equity $ 27,846 $ 8,969
====== ======
<FN>
See accompanying notes to condensed financial statements.
</FN>
</TABLE>
A.P. PHARMA, INC.
- -----------------
CONDENSED STATEMENTS OF OPERATIONS (UNAUDITED)
- ----------------------------------------------
(in thousands, except per share amounts)
- ---------------------------------------

<TABLE>
<CAPTION>

Three Months Ended March 31,
----------------------------
2006 2005
---- ----
<S> <C> <C>

Royalties $ -- $ 1,282
Contract revenues -- 78
------ ------

Total revenues -- 1,360

Operating expenses:
Research & development 3,469 1,822
General & administrative 932 849
------ ------

Total operating expenses 4,401 2,671
------ ------

Operating loss (4,401) (1,311)

Interest income, net 262 72

Gain on sale of interest in royalties 23,421 --

Other income (expense), net 10 (11)
------ ------

Income (Loss) from continuing
operations 19,292 (1,250)

Income (Loss) from discontinued
operations 7 (6)
------ ------

Net income (loss) $19,299 $(1,256)
====== ======

Basic earnings (loss) per share:
Income (Loss) from continuing
operations $ 0.77 $ (0.05)
====== ======
Net income (loss) $ 0.77 $ (0.05)
====== ======

Diluted earnings (loss) per share:
Income (Loss) from continuing
operations $ 0.76 $ (0.05)
====== ======
Net income (loss) $ 0.76 $ (0.05)
====== ======

Weighted average common shares
outstanding-basic 25,207 25,046
====== ======

Weighted average common shares
outstanding-diluted 25,483 25,046
====== ======

<FN>
See accompanying notes to condensed financial statements.
</FN>
</TABLE>
A.P. PHARMA, INC.
- -----------------
CONDENSED STATEMENTS OF CASH FLOWS (UNAUDITED)
- ----------------------------------------------
(in thousands)
- --------------
<TABLE>
<CAPTION>
Three months ended March 31,
----------------------------
2006 2005
---------- ----------
<S> <C> <C>
Cash flows from operating activities:
Net income (loss) $19,299 $(1,256)
Adjustments to reconcile net income
(loss) to net cash provided by (used
in) operating activities:
Gain/loss from discontinued
operations (7) 6
Loss on sale of marketable
securities 1 12
Depreciation and amortization 99 94
SFAS123R stock compensation expense 114 --
Stock and stock option compensation
awards to non-employees 31 29
Restricted stock awards 8 1
Amortization of premium/discount
and accretion of marketable
securities (2) 15
Changes in operating assets and
liabilities:
Accounts receivable 1,426 59
Prepaid expenses and other
current assets (46) 86
Other long-term assets 19 74
Accounts payable (226) (144)
Accrued clinical trial expenses (72) (717)
Other accrued expenses (247) (60)
------ ------
Net cash provided by (used in)
continuing operating activities 20,397 (1,801)

Net cash received from discontinued
operations 21 23

Cash flows from investing activities:
Purchases of property and equipment (29) (26)
Purchases of marketable securities (12,363) (5,156)
Maturities of marketable securities 500 3,792
Sales of marketable securities 1,651 400
------ ------

Net cash used in investing activities (10,241) (990)

Cash flows from financing activities:
Proceeds from the exercise of stock
options 3 11
Proceeds from issuance of restricted
stock -- 1
------ ------
Net cash provided by financing
activities 3 12

Net increase (decrease) in cash and
cash equivalents 10,180 (2,756)
Cash and cash equivalents, beginning
of the period 790 3,110
----- ------
Cash and cash equivalents, end
of the period $10,970 $ 354
===== ======

<FN>
See accompanying notes to condensed financial statements.
</FN>
</TABLE>
A.P. PHARMA, INC.
- -----------------
NOTES TO CONDENSED FINANCIAL STATEMENTS
- -----------------------------------
MARCH 31, 2006 and 2005 (UNAUDITED)
- -----------------------------------

(1) Basis of Presentation
---------------------


A.P. Pharma, Inc. (the "Company", "we", "our", or "us") is
developing patented polymer-based delivery systems to enhance
the safety and effectiveness of pharmaceutical compounds. New
products and technologies under development include bioerodible
polymers for injectable and implantable drug delivery. Projects
have also been conducted under feasibility and development
arrangements with pharmaceutical and biotechnology companies.

In the opinion of management, the accompanying unaudited
condensed financial statements have been prepared in accordance
with U.S. generally accepted accounting principles for interim
financial information and with the instructions to Form 10-Q
and Article 10 of Regulation S-X. Accordingly, they do not
include all of the information and footnotes required by U.S.
generally accepted accounting principles for complete financial
statements. In the opinion of management, all adjustments of a
normal recurring nature considered necessary for a fair
presentation have been included. Operating results for the
three months ended March 31, 2006 are not necessarily
indicative of the results that may be expected for the year
ending December 31, 2006 or any other period. The condensed
balance sheet as of December 31, 2005 has been derived from the
audited financial statements as of that date but it does not
include all of the information and notes required by U.S.
generally accepted accounting principles for complete financial
statements. These condensed financial statements should be
read in conjunction with the financial statements and notes
thereto included in our Annual Report on Form 10-K for the year
ended December 31, 2005.

Summary of Critical Accounting Policies
- ---------------------------------------

Except for the adoption of FAS 123(R) (see Stock-Based
Compensation) we believe there have been no significant changes
in our critical accounting policies during the three months
ended March 31, 2006 compared to those previously disclosed in
our Annual Report on Form 10-K for the year ended December 31,
2005 filed with the U.S. Securities and Exchange Commission
(SEC) on March 31, 2006.

Use of Estimates
- ----------------

The preparation of our financial statements in conformity with
U.S. generally accepted accounting principles requires
management to make estimates and assumptions that affect the
amounts reported in our financial statements and accompanying
notes. Estimates were made relating to useful lives of fixed
assets, valuation allowances, impairment of assets, accrued
clinical and preclinical expenses, valuation of stock-based
compensation and contingencies. Actual results could differ
materially from those estimates.

Revenue Recognition
- -------------------

Our revenue arrangements with multiple deliverables are divided
into separate units of accounting if certain criteria are met,
including whether the delivered element has stand-alone value
to the customer and whether there is objective and reliable
evidence of the fair value of the undelivered elements. The
consideration we receive is allocated among the separate units
based on their respective fair values, and the applicable
revenue recognition criteria are considered separately for each
of the separate units. Advance payments received in excess of
amounts earned are classified as deferred revenue until earned.

* Royalties
Royalties from licensees are based on third-party sales of
licensed products or technologies and recorded as earned in
accordance with contract terms when third-party results can
be reliably determined and collectibility is reasonably
assured.

Generally, contractually required minimum royalties are
recorded ratably throughout the contractual period.
Royalties in excess of minimum royalties are recognized as
earned when the related product is shipped to the end
customer by our licensees based on information provided to
us by our licensees.

* License Fees
Licensing agreements generally provide for periodic minimum
payments, royalties, and/or non-refundable license fees.
These licensing agreements typically require a non-
refundable license fee and allow partners to sell our
proprietary products in a defined field or territory for a
defined period. License agreements provide for the Company
to earn future revenue through royalty payments. These non-
refundable license fees are initially reported as deferred
revenues and recognized as revenues over the estimated life
of the product to which they relate as we have continuing
involvement with licensees until the related product is
discontinued or the related patents expire, whichever is
earlier. License fees received in connection with
arrangements where we have no continuing involvement are
recognized as license fees when the amounts are received or
when collectibility is assured, whichever is earlier. No
such fees were recorded during the three months ended March
31, 2006.

A milestone payment is a payment made by a third party or
corporate partner to us upon the achievement of a
predetermined milestone as defined in a legally binding
contract. Milestone payments are recognized as license fees
when the milestone event has occurred and we have completed
all milestone related services such that the milestone
payment is currently due and is non-refundable. No such
fees were recorded during the three months ended March 31,
2006.

* Contract Revenues
Contract revenues relate to research and development
arrangements that generally provide for the Company to
invoice research and development fees based on full-time
equivalent hours for each project. Revenues from these
arrangements are recognized as the related development costs
are incurred. These revenues approximate the costs
incurred. No such revenues were recorded during the three
months ended March 31, 2006.

Sale of Royalty Revenues
------------------------

In January 2006, we completed the sale of our rights to
royalties on sales of Retin-A Micro(R) and Carac(R) for up to
$30 million. We received proceeds of $25 million upon the
closing of the transaction and we are entitled to receive an
additional $5 million based on the satisfaction of certain
predetermined milestones. The royalty interest agreement was
entered into by the parties in January 2006, but the effective
date of the sale of the royalty interest was October 1, 2005.
The royalties recognized by the Company from October 1, 2005
through December 31, 2005 were accounted for as an offset
against the $25 million gain.

Cash Equivalents and Short-term Investments
- -------------------------------------------

We consider all short-term investments in debt securities which
have original maturities of less than three months at date of
purchase to be cash equivalents. Investments which have
original maturities of three months or longer are classified as
marketable securities in the accompanying condensed balance
sheets.

Accrued Disposition Costs
- -------------------------

Costs relating to disposal of discontinued operations are
reported as accrued disposition costs in the accompanying
condensed balance sheets. Accrued disposition costs include
severance costs and gross profit guarantees.

Concentrations of Credit Risk
- -----------------------------

Financial instruments that potentially subject us to
concentrations of credit risk consist primarily of cash
equivalents, short-term investments and trade accounts
receivable. We invest excess cash in a variety of high grade
short-term, interest-bearing securities. This diversification
of risk is consistent with our policy to ensure safety of
principal and to maintain liquidity.

Segment and Geographic Information
- ----------------------------------

Our operations are confined to a single business segment, the
design and commercialization of polymer technologies for
pharmaceutical and other applications. Substantially all of
our revenues are derived from domestic customers.

Stock-Based Compensation
- ------------------------

Refer to Note 2 "Stock-Based Compensation" and Note 8
Stockholders' Equity in our 2005 Annual Report for further
information regarding our adoption of SFAS 123(R) and our
stock-based compensation arrangements, including related
disclosures required upon the adoption of SFAS 123(R). On
January 1, 2006, we adopted the provisions of Financial
Accounting Standards Board Statement No. 123R, "Share-Based
Payment" (SFAS 123R). SFAS 123R revised SFAS 123, "Accounting
for Stock-Based Compensation" and supersedes APB Opinion No.
25, "Accounting for Stock Issued to Employees." SFAS 123R
requires companies to measure and recognize compensation
expense for all employee share-based payments at fair value
over the service period underlying the arrangement. Therefore,
we are required to record the grant-date or purchase-date fair
value of stock options issued to employees and employee stock
purchases. We have recorded the compensation expense for stock
options issued to non-employees and restricted stock awards to
employees and directors. Compensation related to options
granted to non-employees is periodically remeasured as earned.
We adopted SFAS 123R using the "modified prospective" method,
whereby fair value of all previously-granted employee share-
based arrangements that remained unvested at January 1, 2006,
based on the grant-date value estimated in accordance with the
pro forma provisions of SFAS 123, and all grants made on or
after January 1, 2006, based on fair value estimated in
accordance with SFAS 123(R), have been included in our
determination of share-based compensation expense for the three
months ended March 31, 2006. We have not restated our
operating results for the three months ended March 31, 2005 to
reflect charges for the fair value of share-based arrangements.

We use the Black-Scholes option-pricing model with the
following weighted-average assumptions to estimate stock
compensation expense for the three months ended March 31, 2006:
1) risk-free interest rate of 4.4% for stock options and 3.4%
for employee stock purchase plan; 2) expected dividend yield of
0% for both stock options and employee stock purchase plan; 3)
expected holding period of 6.25 years based on the simplified
method provided in Staff Accounting Bulletin No. 107 for "plain
vanilla options" and expected term of 1.25 years for employee
stock purchase plan based on weighted-average purchase period
of the plan; 4) expected volatility of 240% for stock options
and 106% for employee stock purchase plan based on the
Company's historical stock prices; and 5) an estimated
forfeiture rate of 3% of the options granted based on
historical data.

The SFAS 123R share-based compensation expenses recorded for
awards granted under the stock option plans and employee stock
purchase plan were approximately $114,000, net of estimated
forfeitures, for the three months ended March 31, 2006. The
share-based compensation expense of $53,000 and $61,000 was
recorded in research and development expense and general and
administrative expense, respectively. No tax benefit was
recognized related to share-based compensation expense since we
have incurred operating losses and we have established a full
valuation allowance to offset all the potential tax benefits
associated with our deferred tax assets.

During the three months ended March 31, 2006 we granted 214,940
options to employees to purchase common stocks. The following
table summarizes option activity for the three months ended
March 31, 2006:
<TABLE>
<CAPTION>
Weighted Average
Shares Exercise Price
------ ---------------
<S> <C> <C>
Outstanding at January 1, 2006 2,165,966 $3.40
Granted 214,940 $1.62
Exercised (1,797) $1.55
Expired or forfeited (11,335) $1.66
---------
Outstanding at March 31, 2006 2,367,774 $3.25
=========
Options exercisable at
March 31, 2006 1,870,718 $3.67
</TABLE>

The following table summarizes our non-vested share activity
for the three months ended March 31, 2006.

<TABLE>
<CAPTION>
Shares
------
<S> <C>
Outstanding at January 1, 2006 337,133
Granted 214,940
Vested (43,682)
Forfeited (11,335)
-------
Outstanding at March 31, 2006 497,056
=======
</TABLE>

As of March 31, 2006 there was approximately $604,000 of total
unrecognized compensation expense related to nonvested stock
options. This expense is expected to be recognized over a
weighted-average period of 1.33 years.

Prior to January 1, 2006, we accounted for employee stock-based
grants in accordance with SFAS No. 123, "Accounting for Stock-
Based Compensation," as amended by SFAS No. 148, "Accounting
for Stock-Based Compensation-Transition and Disclosure". We
have provided below the pro forma disclosures of the effect on
net loss and net loss per share as if SFAS No. 123 had been
applied in measuring compensation expense for the three months
ended March 31, 2005.

<TABLE>
<CAPTION>
Three Months Ended
March 31,
------------------
2005
----
<S> <C>
Net loss, as reported $(1,256)
Deduct:
Stock-based employee
compensation expense
determined under SFAS No. 123 (84)
------
Pro forma net loss $(1,340)
======
Basic and diluted net loss per
share, as reported $ (0.05)
======
Basic and diluted pro forma
net loss per share $ (0.05)
======
</TABLE>

Fair values of awards granted under the stock option plans and
employee stock purchase plan were estimated at grant date using
the Black-Scholes option pricing model. For pro forma
disclosure, the estimated fair value of the options is
amortized to expense over the vesting period of the options
using the straight line method. Forfeitures have been
accounted for in the period in which they occurred. The
multiple option approach is used to value the purchase rights
granted under the employee stock purchase plan. We used the
following assumptions for the three months ended March 31,
2005:

<TABLE>
<CAPTION>
Three Months Ended
March 31,
------------------
2005
----
<S> <C>
Expected life in years (from
grant date):
Stock options 5
Employee stock purchase plan 1.5 - 2
Interest rate:
Stock options 4.2%
Employee stock purchase plan 1.47%-2.6%
Volatility:
Stock options 79%
Employee stock purchase plan 65%-147%
Expected dividend yield: 0%
</TABLE>

Reclassifications
- -----------------

Certain amounts in the prior quarter condensed financial
statements have been reclassified to conform with the current
presentation of the financial statements. Amortization of
premium/discount and accretion of marketable securities in the
prior quarter have been reclassified from investing activities
to operating activities on the Condensed Statements of Cash
Flows.

(2) Income (Loss) Per Share Information
-----------------------------------

Basic income (loss) per share is computed by dividing net
income (loss) by the weighted-average number of common shares
outstanding. Because the Company is in a net loss position for
the three months ended March 31, 2005, diluted earnings per
share is also calculated using the weighted average number of
common shares outstanding and excludes the effects of options
which are antidilutive. For the three months ended March 31,
2006, diluted earnings per share is calculated using the
weighted average number of common shares outstanding and other
dilutive securities.

The following is a reconciliation of the numerators and
denominators of the basic and diluted earnings per share
computations (in thousands):

<TABLE>
<CAPTION>
Three Months Ended
March 31,
------------------
2006 2005
---- ----
<S> <C> <C>
Numerator:
Net income (loss) $19,299 $(1,256)
====== ======

Denominator:
Weighted-average shares
outstanding used to compute
basic earnings per share 25,207 25,046
Effect of dilutive stock options
and restricted stock awards 276 --
------ ------

Weighted-average shares
outstanding and dilutive
securities used to compute
diluted earnings per share 25,483 25,046
====== ======
</TABLE>

(3) Comprehensive Income (Loss)
---------------------------
Comprehensive income (loss) for the three months ended March
31, 2006 and 2005 consists of the following (in thousands):

<TABLE>
<CAPTION>
Three Months Ended
March 31,
------------------
2006 2005
---- ----
<S> <C> <C>
Net income (loss) $19,299 $(1,256)

Unrealized (losses) gains on
available-for-sale securities (29) 3
------ ------

Comprehensive income (loss) $19,270 $(1,253)
====== ======
</TABLE>

(4) Stockholders' Equity
--------------------

During the three months ended March 31, 2006, 21,078 shares of
common stock were issued primarily through the exercise of
stock options by employees and for the payment of directors'
fees.

(5) Discontinued Operations
-----------------------

We completed the sale of certain assets of our Analytical
Standards division as well as certain technology rights for our
topical pharmaceutical and cosmeceutical product lines and
other assets ("cosmeceutical and toiletry business") in
February 2003 and July 2000, respectively.

The Analytical Standards division and cosmeceutical and
toiletry business are reported as discontinued operations for
all periods presented in the accompanying Condensed Statements
of Operations.

Income (loss) from discontinued operations represents the
income (loss) attributable to our Analytical Standards division
that was sold to GFS Chemicals on February 13, 2003, and
changes in estimates for our cosmeceutical and toiletry
business that was sold to RP Scherer on July 25, 2000, as
follows (in thousands):


<TABLE>
<CAPTION>
For the Three
Months Ended
March 31,
-------------
2006 2005
---- ----
<S> <C> <C>
Analytical Standards Division
- -----------------------------
Royalties earned in excess of
minimum amount recorded $ 7 $ 12

Cosmeceutical and Toiletry Business
- -----------------------------------
Change in estimates for gross
profit guarantees -- (18)
---- ----
Total income (loss) from discontinued
operations $ 7 $ (6)
==== ====
</TABLE>

Basic and diluted income (loss) per common share from
discontinued operations were less than $0.01 per share for the
three months ended March 31, 2006 and 2005, respectively.

Liabilities related to the discontinued operations at March 31,
2006 in the amount of $245,000 include severance costs and
accruals for gross profit guarantees. These liabilities are
reported as accrued disposition costs in the accompanying
condensed balance sheets.

Under the terms of the agreement with RP Scherer, we guaranteed
a minimum gross profit percentage on RP Scherer's combined
sales of products to Ortho Neutrogena and Dermik ("Gross Profit
Guaranty"). The guaranty period commenced on July 1, 2000 and
ends on the earlier of July 1, 2010 or the end of two
consecutive guaranty periods where the combined gross profit on
sales to Ortho and Dermik equals or exceeds the guaranteed
gross profit. We expect the annual Gross Profit Guaranty
payments to range from approximately $100,000 to $150,000 for
the remainder of the guaranty period. As the minimum amount of
Gross Profit Guaranty due is based on sales by RP Scherer and
can not be estimated, no accrual has been recorded relating to
sales in future periods.

Cash provided by discontinued operations primarily relates to
royalty payments received from GFS Chemicals for the sale of
certain products.

Below is a summary of activity for liabilities related to the
discontinued operations for the three months ended March 31,
2006 (in thousands):

<TABLE>
<CAPTION>
<S> <C>
Accrual at December 31, 2005 $248
Payment under severance agreement (3)
---
Accrual at March 31, 2006 $245
===
</TABLE>
ITEM 2. Management's Discussion and Analysis of Financial Condition
-----------------------------------------------------------
and Results of Operations (all dollar amounts rounded to the
------------------------------------------------------------
nearest thousand)
-----------------

FORWARD-LOOKING STATEMENTS

Except for statements of historical fact, the statements herein are
forward-looking and are subject to a number of risks and
uncertainties that could cause actual results to differ materially
from the statements made. These include, among others, uncertainty
associated with timely development, approval, launch and acceptance
of new products, establishment of new corporate alliances, progress
in research and development programs, and other risks described
below or identified from time to time in our Securities and Exchange
Commission filings. Except as may be required by law, we undertake
no obligation to update any forward-looking statement to reflect
events after the date of this report.

CRITICAL ACCOUNTING POLICIES AND ESTIMATES

The preparation of our financial statements in conformity with U.S.
generally accepted accounting principles requires management to make
estimates and assumptions that affect the amounts reported in our
financial statements and accompanying notes. On an ongoing basis,
we evaluate our estimates including those related to the useful
lives of fixed assets, valuation allowances, impairment of assets,
accrued clinical and preclinical expenses, valuation of stock-based
compensation and contingencies. Actual results could differ
materially from those estimates.

Except for the adoption of SFAS 123(R) we believe there have been no
significant changes in our critical accounting policies and
estimates during the three months ended March 31, 2006 compared to
those previously disclosed in our Annual Report on Form 10-K for the
year ended December 31, 2005 filed with the SEC on March 31, 2006.
For a description of our critical accounting policies and estimates,
please refer to our Annual Report on Form 10-K for the year ended
December 31, 2005.

On January 1, 2006, we adopted the provisions of Financial
Accounting Standards Board Statement No. 123R, "Share-Based Payment"
(SFAS 123R). SFAS 123R revised SFAS 123, "Accounting for Stock-
Based Compensation" and supersedes APB Opinion No. 25, "Accounting
for Stock Issued to Employees." SFAS 123R requires companies to
measure and recognize compensation expense for all employee share-
based payments at fair value over the service period underlying the
arrangement. Therefore, we are required to record the grant-date or
purchase-date fair value of stock options issued to employees and
employee stock purchases. We have recorded the compensation
expenses for stock options issued to non-employees and restricted
stock awards to employees and directors. Compensation related to
options granted to non-employees is periodically remeasured as
earned. We adopted SFAS 123R using the "modified prospective"
method, whereby fair value of all previously-granted employee share-
based arrangements that remained unvested at January 1, 2006 and all
grants made on or after January 1, 2006 have been included in our
determination of share-based compensation expense for the three
months ended March 31, 2006. We have not restated our operating
results for the three months ended March 31, 2005 to reflect charges
for the fair value of share-based arrangements.

Results of Operations for the Three Months Ended March 31, 2006 and
- -------------------------------------------------------------------
2005
- ----

Our revenues have been derived principally from royalties and
contract revenues. Under strategic alliance arrangements entered
into with certain companies, we received non-refundable upfront
fees, milestone payments and royalties based on third party product
sales.

In January 2006, we completed the sale of our rights to royalties on
sales of Retin-A Micro(R) and Carac(R) for up to $30 million. We
received proceeds of $25 million upon the closing of the transaction
and we are entitled to receive an additional $5 million based on the
satisfaction of certain predetermined milestones. The royalty
interest agreement was entered into by the parties in January 2006,
but the effective date of the sale of the royalty interest was
October 1, 2005. The royalties recognized by the Company from
October 1, 2005 through December 31, 2005 were accounted for as an
offset against the $25 million gain. As a result of this
transaction, royalties for the first quarter of 2006 decreased to $0
from $1,282,000 in the corresponding quarter of the prior year. We
will not record additional royalty revenue on sales of Retin-A Micro
and Carac in future periods.

Contract revenues, which are derived from work performed under
collaborative research and development arrangements, decreased by
$78,000 from $78,000 to $0 in the first quarter of 2006. The amount
of contract revenues varies from period to period depending on the
level of activity requested of us by our collaborators. Therefore
we can not predict the amount of contract revenues in future
periods.

Research and development expense for the first quarter of 2006
increased by $1,647,000 from $1,822,000 to $3,469,000 due mainly to
expenditures in the first quarter on preparations for a Phase 3
study for APF530, our product candidate for the prevention of
chemotherapy-induced nausea and vomiting. We expect research and
development expense to increase in the second quarter of 2006 as we
initiate our Phase 3 trial program for APF530.

General and administrative expense increased for the first quarter
of 2006 by $83,000 from $849,000 to $932,000 due primarily to
increased use of outside consultants and increased legal fees. We
expect general and administrative expense to increase slightly
through the end of the year compared to 2005.

With the adoption of SFAS 123R, we expect an increase in our non-
cash operating expenses for employee share-based compensation in all
future periods.

Interest income, net, increased for the first quarter of 2006 by
$190,000 to $262,000 from $72,000 due to higher interest rates
earned on higher average cash and marketable securities balances.

Income/loss from discontinued operations represents the net
income/loss attributable to the Analytical Standards division which
was sold to GFS Chemicals, Inc. in February 2003 and the
cosmeceutical and toiletries business which was sold to RP Scherer
Corporation in July 2000. Net income from discontinued operations
totaled $7,000 for the three months ended March 31, 2006, compared
with a net loss of $6,000 in the three months ended March 31, 2005.

Capital Resources and Liquidity
- -------------------------------

Cash, cash equivalents and marketable securities increased by
$20,363,000 to $26,172,000 at March 31, 2006 from $5,809,000 at
December 31, 2005 due to the sale of our interest in royalties on
sales of Retin-A Micro and Carac in January 2006, partially offset
by cash used in operating activities.

Net cash provided by continuing operating activities for the three
months ended March 31, 2006 was $20,397,000, compared to net cash of
$1,801,000 used in continuing operating activities for the three
months ended March 31, 2005. The increase in net cash provided by
operating activities from 2005 to 2006 was mainly due to proceeds
from the sale of our interest in royalties in January 2006.

Net cash used in investing activities for the three months ended
March 31, 2006 and 2005 was $10,241,000 and $990,000, respectively.
The increase in the cash used in investing activities was primarily
due to the purchases of $12,363,000 of marketable securities.

To date, we have financed our operations including technology and
product research and development, primarily through royalties
received on sales of Retin-A Micro and Carac, income from
collaborative research and development fees, the proceeds received
from the sales of our Analytical Standards division, our
cosmeceutical and toiletry business and our interest in royalties on
sales of Retin-A Micro(R) and Carac(R), the sale of common stock in
June 2004, and interest earned on short-term investments. Our
existing cash and cash equivalents, marketable securities, together
with interest income and other revenue-producing activities
including license and option fees and research and development fees,
are expected to be sufficient to meet our cash needs for at least
the next year. It is possible that we will seek additional
financing within this timeline through collaborative agreements,
debt financing, equity financing, the sale of certain assets and
technology rights or other arrangements.

Our future capital requirements will depend on numerous factors
including, among others, our ability to enter into collaborative
research and development and licensing agreements; progress of
product candidates in preclinical and clinical trials; investment in
new research and development programs; time required to gain
regulatory approvals; resources that we devote to self-funded
products; potential acquisitions of technology, product candidates
or businesses; and the costs of defending or prosecuting any patent
opposition or litigation necessary to protect our proprietary
technology.

Our capital resources will be unable to meet our long term capital
requirements. We are actively seeking partners in the U.S. and
abroad to take over the funding of the Phase 3 clinical trial of
APF530, and to commercialize the product upon approval by the FDA.
If we are unable to reach terms with a partner, we will have to
raise additional funds. We may be unable to raise sufficient
additional capital when we need it or to raise capital on favorable
terms. The sale of equity or convertible debt securities in the
future may be dilutive to our stockholders, and debt financing
arrangements may require us to pledge certain assets and enter into
covenants that could restrict certain business activities or our
ability to incur further indebtedness and may contain other terms
that are not favorable to us or our stockholders. If we are unable
to obtain adequate funds on reasonable terms, we may be required to
curtail operations significantly or to obtain funds by entering into
financing, supply or collaboration agreements on unattractive terms.

Below is a summary of fixed payments related to certain contractual
obligations (in thousands). This table excludes amounts already
recorded on our condensed balance sheet as current liabilities at
March 31, 2006.

<TABLE>
<CAPTION>
Less More
than 2 to 3 4 to 5 than
Total 1 year years years 5 years
----- ------ ------ ------ -------
<S> <C> <C> <C> <C> <C>
Operating Leases $2,378 $475 $949 $954 $ --
===== === === === ===
</TABLE>


ITEM 3. Quantitative and Qualitative Disclosure about Market Risk
----------------------------------------------------------

Since December 31, 2005, there have been no material changes in the
Company's market risk exposure.

ITEM 4. Controls and Procedures
-----------------------

Evaluation of disclosure controls and procedures: We carried out an
evaluation, under the supervision and with the participation of our
management, including the Chief Executive Officer and Chief
Financial Officer, of the effectiveness of the design and operations
of our disclosure controls and procedures pursuant to Rule 13a-15(e)
and 15(d)-15(e) of the Exchange Act. Based upon that evaluation,
the Chief Executive Officer and Chief Financial Officer concluded
that as of March 31, 2006, the end of period covered by this report,
our disclosure controls and procedures were effective at the
reasonable assurance level to alert them in a timely manner to
material information relating to the Company required to be included
in our Exchange Act filings.

Changes in internal controls: During the three months ended March
31, 2006, there have been no significant changes in our internal
control over financial reporting that materially affected, or are
reasonably likely to materially affect, our internal control over
financial reporting.
PART II. OTHER INFORMATION
-----------------

ITEM 1A. Risk Factors

There have been no material changes to the risk factors set forth
in the "RISK FACTORS" section of our Annual Report on Form 10-K for the
fiscal year ended December 31, 2005.

ITEM 6. Exhibits
--------

Exhibit 10.1 Royalty Interest Agreement, dated as of January 17,
2006, between A.P. Pharma, Inc. and an affiliate of Paul Royalty Fund
II, L.P.

Exhibit 10.2 Security Agreement, dated as of January 17, 2006,
between A.P. Pharma, Inc. and an affiliate of Paul Royalty Fund II,
L.P.

Exhibit 31.1 Certification of Chief Executive Officer pursuant to
Rules 13A-15(e) Promulgated under the Securities Exchange Act of 1934
as amended.

Exhibit 31.2 Certification of Chief Financial Officer pursuant to
Rules 13A-15(e) Promulgated under the Securities Exchange Act of 1934
as amended.

Exhibit 32 Certifications of Chief Executive Officer and Chief
Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted
pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.
SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its
behalf by the undersigned thereunto duly authorized.


A.P. PHARMA, INC.



Date: May 12, 2006 By: /S/ Michael O'Connell
------------------ -----------------------
Michael O'Connell
President and Chief
Executive Officer



Date: May 12, 2006 By: /S/ Gordon Sangster
------------------ ---------------------
Gordon Sangster
Chief Financial Officer