According to Upstream Bio's latest financial reports and stock price the company's current Operating Margin is -5,382.64%. At the end of 2025 the company had an Operating Margin of -5,026.03%.
The operating margin is a key indicator to assess the profitability of a company. Higher operating margins are generaly better as they show that a company is able to sell its products or services for much more than their production costs. The operating margin is calculated by dividing a company's earnings by its revenue.