Integra LifeSciences
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Integra LifeSciences - 10-Q quarterly report FY


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SECURITIES AND EXCHANGE COMMISSION
Washington, DC 20549

FORM 10-Q

QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(D)
OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended March 31, 2000

Commission file number 0-26224

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
(Exact name of registrant as specified in its charter)

Delaware 51-0317849
(State or other jurisdiction of (I.R.S. Employer
incorporation or organization) Identification No.)

105 Morgan Lane
Plainsboro, New Jersey 08536
(Address of principal executive offices) (Zip code)

(609) 275-0500
(Registrant's telephone number, including area code)

Indicate by check mark whether the registrant: (1)
has filed all reports required to be filed by Section
13 or 15(d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such
shorter period that the registrant was required to
file such reports), and (2) has been subject to
such filing requirements for the past 90 days.
/X/ - Yes / / - No

As of May 5, 2000 the registrant had outstanding 16,347,810 shares of
Common Stock, $.01 par value.
INTEGRA LIFESCIENCES HOLDINGS CORPORATION

INDEX


Page Number
-----------

PART I. FINANCIAL INFORMATION

Item 1. Financial Statements

Consolidated Balance Sheets as of March 31, 2000 and
December 31, 1999 (Unaudited) 3

Consolidated Statements of Operations for the three months
ended March 31, 2000 and 1999 (Unaudited) 4

Consolidated Statements of Cash Flows for the three months
ended March 31, 2000 and 1999 (Unaudited) 5

Notes to Unaudited Consolidated Financial Statements 6

Item 2. Management's Discussion and Analysis of Financial
Condition and Results of Operations 11

PART II. OTHER INFORMATION

Item 1. Legal Proceedings 16

Item 2. Changes in Securities and Use of Proceeds 16

Item 6. Exhibits and Reports on Form 8-K 16

SIGNATURES 18

Exhibits 19


2
PART I.  FINANCIAL INFORMATION

Item 1. Financial Statements

INTEGRA LIFESCIENCES HOLDINGS CORPORATION AND SUBSIDIARIES
CONSOLIDATED BALANCE SHEETS
(UNAUDITED)

<TABLE>
<CAPTION>

(In thousands)
March 31, 2000 December 31, 1999
-------------- -----------------
<S> <C> <C>
ASSETS
Current Assets:
Cash and cash equivalents......................................... $ 23,366 $ 19,301
Short-term investments............................................ 206 4,311
Accounts receivable, net of allowances of $944 and $944........... 8,719 8,365
Inventories....................................................... 10,667 10,111
Prepaid expenses and other current assets......................... 695 718
---------- ----------
Total current assets.......................................... 43,653 42,806
Property and equipment, net........................................... 10,547 9,699
Goodwill and intangible assets, net................................... 18,809 13,219
Other assets.......................................................... 684 529
---------- ----------
Total assets....................................................... $ 73,693 $ 66,253
========== ==========

LIABILITIES AND STOCKHOLDERS' EQUITY
Current Liabilities:
Short-term loans and current maturities of long-term loans.......... $ 2,601 $ 2,254
Current portion of note payable..................................... 1,450 --
Accounts payable, trade............................................. 1,717 994
Accrued expenses.................................................... 5,484 5,540
Income taxes payable................................................ 751 643
Customer advances and deposits...................................... 3,100 3,901
Deferred revenue.................................................... 1,276 1,460
---------- ----------
Total current liabilities..................................... 16,379 14,792
Long-term loan........................................................ 7,000 7,625
Note payable.......................................................... 1,204 --
Deferred revenue...................................................... 4,824 5,049
Other liabilities..................................................... 804 798
---------- ----------
Total liabilities............................................. 30,211 28,264
---------- ----------
Commitments and contingencies

Stockholders' Equity:
Preferred stock, $.01 par value (15,000 authorized shares; 500 Series A
Convertible shares issued and outstanding at March 31, 2000 and December 31,
1999, $4,000 liquidation preference; 100 Series B Convertible shares issued
and outstanding at March 31, 2000 and December 31, 1999, $10,100 with a 10%
compounded annual dividend liquidation preference; 54 Series C Convertible
shares issued and outstanding at March 31, 2000, $5,400 with a 10% compounded
annual dividend liquidation preference).............................. 7 6
Common stock, $.01 par value (60,000 authorized shares; 16,314 and
16,131 shares issued at March 31, 2000 and December 31,
1999, respectively).................................................. 163 161
Additional paid-in capital............................................. 138,754 132,340
Treasury stock, cost (1 share at March 31, 2000 and December 31, 1999). (7) (7)
Other.................................................................. (128) (143)
Accumulated other comprehensive income (loss).......................... 60 (64)
Accumulated deficit.................................................... (95,367) (94,304)
---------- ----------
Total stockholders' equity.................................... 43,482 37,989
---------- ----------
Total liabilities and stockholders' equity............................ $ 73,693 $ 66,253
========== ==========
</TABLE>

The accompanying notes are an integral part of the
consolidated financial statements


3
INTEGRA LIFESCIENCES HOLDINGS CORPORATION AND SUBSIDIARIES
CONSOLIDATED STATEMENTS OF OPERATIONS
(UNAUDITED)

(In thousands, except per share amounts)

<TABLE>
<CAPTION>

Three Months Ended March 31,
2000 1999
---- ----
<S> <C> <C>
REVENUES
Product sales ........................................................... $ 13,236 $ 4,605
Other revenue ........................................................... 1,171 363
-------- --------
Total revenue ........................................................ 14,407 4,968

COSTS AND EXPENSES
Cost of product sales, including depreciation
of $370 and $292 ..................................................... 6,592 2,694
Research and development ................................................ 1,828 1,940
Selling and marketing ................................................... 2,917 1,560
General and administrative .............................................. 3,608 2,151
Amortization and other depreciation ..................................... 712 151
-------- --------
Total costs and expenses ............................................. 15,657 8,496

Operating loss .......................................................... (1,250) (3,528)

Interest income ......................................................... 291 278
Interest expense ........................................................ (280) (27)
Gain on disposition of product line ..................................... 115 4,161
Other income ............................................................ 123 2
-------- --------
Net income (loss) before income taxes ................................... (1,001) 886

Provision for income taxes .............................................. 62 460
-------- --------
Net income (loss) ....................................................... $ (1,063) $ 426
======== ========

Basic net income (loss) per share ....................................... $ (0.32) $ 0.02
Diluted net income (loss) per share ..................................... $ (0.32) $ 0.02

Weighted average common shares outstanding
Basic ................................................................ 17,224 16,731
Diluted .............................................................. 17,224 17,256
</TABLE>


The accompanying notes are an integral part of the
consolidated financial statements


4
INTEGRA LIFESCIENCES HOLDINGS CORPORATION AND SUBSIDIARIES
CONSOLIDATED STATEMENTS OF CASH FLOWS
(UNAUDITED)
<TABLE>
<CAPTION>

(In thousands)
Three Months Ended March 31,
----------------------------
2000 1999
---- ----
<S> <C> <C>
OPERATING ACTIVITIES:

Net income (loss)...................................................... $ (1,063) $ 426
Adjustments to reconcile net income (loss) to net cash used in
operating activities:
Depreciation and amortization....................................... 1,082 443
Gain on sale of product line and investments........................ (326) (4,161)
Amortization of discount and interest on investments................ -- (104)
Amortization of unearned compensation............................... 24 50
Changes in assets and liabilities, net of business acquisitions:
Accounts receivable.............................................. (353) (712)
Inventories...................................................... 104 452
Prepaid expenses and other current assets........................ (31) (51)
Non-current assets............................................... (221) (21)
Accounts payable, accrued expenses and other liabilities......... 734 755
Customer advances and deposits................................... (801) 244
Deferred revenue................................................. (409) --
-------- --------
Net cash used in operating activities............................... (1,260) (2,679)
-------- --------

INVESTING ACTIVITIES:

Proceeds from sale of product line and other assets.................... 150 6,354
Proceeds from sale/maturity of investments............................. 15,072 6,000
Purchases of available-for-sale investments............................ (10,601) (2,966)
Cash used in business acquisition, net of cash acquired................ (4,075) (13,935)
Purchases of property and equipment.................................... (1,351) (388)
-------- --------
Net cash used in investing activities............................... (805) (4,935)
-------- --------

FINANCING ACTIVITIES:

Net proceeds from revolving credit facility............................ 97 --
Repayments of term loan................................................ (375) --
Proceeds from sale of preferred stock.................................. 5,375 10,000
Proceeds from exercised stock options.................................. 1,053 --
Treasury stock purchases............................................... -- --
Preferred dividends paid............................................... (20) (20)
-------- --------
Net cash provided by financing activities........................... 6,130 9,980
-------- --------

Net increase in cash and cash equivalents.................................. 4,065 2,366

Cash and cash equivalents at beginning of period........................... 19,301 5,277
-------- --------
Cash and cash equivalents at end of period................................. $ 23,366 $ 7,643
======== ========

Non-cash investing and financing activities:

Note issued in a business acquisition................................. $ 2,654 $ --
Term loan assumed in connection with a business acquisition........... -- 11,000
</TABLE>


The accompanying notes are an integral part of the
consolidated financial statements

5
INTEGRA LIFESCIENCES HOLDINGS CORPORATION AND SUBSIDIARIES
NOTES TO UNAUDITED CONSOLIDATED FINANCIAL STATEMENTS
(UNAUDITED)

1. General

In the opinion of management, the March 31 unaudited consolidated financial
statements contain all adjustments (consisting only of normal recurring
accruals) which the Company considers necessary for a fair presentation of the
financial position and results of operations of the Company. Operating results
for the three-month period ended March 31, 2000 are not necessarily indicative
of the results to be expected for the entire year. Certain information and
footnote disclosures normally included in financial statements prepared in
accordance with generally accepted accounting principles have been condensed or
omitted. The preparation of financial statements in conformity with generally
accepted accounting principles requires management to make estimates and
assumptions that affect the reported amounts of assets and liabilities,
including disclosures of contingent assets and liabilities and the reported
amounts of revenues and expenses during the reporting periods. Actual results
could differ from those estimates. These unaudited consolidated financial
statements should be read in conjunction with the Company's consolidated
financial statements for the year ended December 31, 1999 included in the
Company's Annual Report on Form 10-K.

2. Acquisition

On January 17, 2000, the Company purchased the business, including certain
assets and liabilities, of Clinical Neuro Systems, Inc. ("CNS") for $6.8
million. CNS designs, manufactures and sells neurosurgical external ventricular
drainage systems, including catheters and drainage bags, as well as cranial
access kits. The purchase price consisted of $4.0 million in cash and a 5% $2.8
million promissory note issued to the seller. The promissory note, which is
payable in two principal payments of $1.4 million each, plus accrued interest,
in January 2001 and 2002, is collateralized by inventory, property and equipment
of the CNS business and by a collateral assignment of a $2.8 million promissory
note from one of the Company's subsidiaries.

This acquisition has been accounted for using the purchase method of accounting,
and the results of operations of the acquired business have been included in the
consolidated financial statements since the date of acquisition. The allocation
of the purchase price resulted in acquired intangible assets, consisting
primarily of completed technology, customer list and trademarks, of $4.2 million
and residual goodwill of $1.8 million, which are being amortized on a
straight-line basis over a weighted average life of 14 years and 15 years,
respectively.

The following unaudited pro forma financial information assumes that the
acquisition had occurred as of the beginning of each period (in thousands):

For the Three Months
Ended March 31,
2000 1999
----- -----
Total revenue ....................... $14,577 $ 5,524
Net loss ............................ (1,004) (3,448)
Basic and diluted loss per share..... $ (0.32) $ (0.21)

Excluded from the pro forma results for the three months ended March 31, 1999 is
the $3.7 million gain, net of tax ($0.22 per share), from the sale of a product
line. The pro forma results do not necessarily represent results that would have
occurred if the acquisition had taken place on the basis assumed above, nor are
they indicative of the results of future combined operations.


6
INTEGRA LIFESCIENCES HOLDINGS CORPORATION AND SUBSIDIARIES
NOTES TO UNAUDITED CONSOLIDATED FINANCIAL STATEMENTS
(UNAUDITED)

3. Issuance of Series C Preferred Stock

On March 29, 2000, the Company issued 54,000 shares of Series C Convertible
Preferred Stock ("Series C Preferred") and warrants to purchase 300,000 shares
of common stock at $9.00 per share to affiliates of Soros Private Equity
Partners LLC for $5,374,000, net of issuance costs. The Series C Preferred is
convertible into 600,000 shares of common stock and has a liquidation preference
of $5.4 million with a 10% annual cumulative dividend associated with the
liquidation preference. The Series C Preferred was issued with a beneficial
conversion feature that resulted in a nonrecurring, non-cash dividend of
$4,170,000, which has been reflected in the net loss per share applicable to
common stock for the three months ended March 31, 2000. The beneficial
conversion dividend is based upon the excess of the closing price of the
underlying common stock as compared to the fixed conversion price of the Series
C Preferred Stock, after taking into account the value assigned to the common
stock warrants.

4. Income (Loss) per Share

Basic and diluted net income (loss) per share for the three months ended March
31 were as follows:

<TABLE>
<CAPTION>

2000 1999
----- -----
(In thousands)
<S> <C> <C>
Basic per share computation:
Net income (loss)................................ $ (1,063) $ 426
Dividends on Series A preferred stock............ (20) (20)
Dividends on Series B preferred stock............ (275) --
Beneficial conversion feature on Series C
preferred stock.............................. (4,170) --
-------- --------
Net income (loss) available to common stock...... $ (5,528) $ 406
======== ========

Average number of shares outstanding............. 17,224 16,731
Basic net income (loss) per share................ $ (0.32) $ 0.02
======== ========
Diluted per share computation:
Net income (loss) available to common stock...... $ (5,528) $ 426

Average number of shares outstanding............. 17,224 16,731
Effect of dilutive stock options................. -- 187
Effect of preferred stock and dilutive warrants.. -- 338
-------- --------
Average dilutive number of shares outstanding.... 17,224 17,256
======== ========
Diluted net income (loss) per share.............. $ (0.32) $ 0.02
======== ========
</TABLE>

Option and warrants to purchase 3,732,562 shares of common stock and preferred
stock convertible into 3,467,801 shares of common stock at March 31, 2000 were
not included in the computation of diluted net loss per share for the three
months ended March 31, 2000 because their effect would have been antidilutive.
Options and warrants to purchase 2,539,068 shares of common stock (at a price
range of $4.31 to $23.00) outstanding at March 31, 1999 were not included in the
computation of diluted net income per share for the three months ended March 31,
1999 because the exercise prices were greater than the average market price of
the common stock for the period.


7
INTEGRA LIFESCIENCES HOLDINGS CORPORATION AND SUBSIDIARIES
NOTES TO UNAUDITED CONSOLIDATED FINANCIAL STATEMENTS
(UNAUDITED)

5. Comprehensive Income (Loss)

Comprehensive income (loss) for the three months ended March 31 was as follows:

2000 1999
-------- --------
(In thousands)

Net income (loss).............................. $ (1,063) $ 426

Unrealized gains on investments................ 300 16
Reclassification adjustment for gains
included in net income..................... (176) --
-------- --------
Comprehensive income (loss).................... $ (939) $ 442
======== ========


6. Inventories

Inventories consist of the following:
March 31, December 31,
2000 1999
-------- -----------
(In thousands)

Finished goods........... $ 4,363 $ 3,786
Work-in-process.......... 2,962 2,224
Raw materials............ 3,342 4,101
-------- --------
$10,667 $ 10,111
======== ========

7. Current Liabilities

Accrued expenses consist of the following:

March 31, December 31,
2000 1999
-------- ----------
(In thousands)

Legal fees................... $ 702 $ 526
Vacation..................... 578 533
Acquisition related costs.... -- 658
Contract research............ 359 378
Other........................ 3,845 3,445
-------- --------
$ 5,484 $ 5,540
======== ========


8
INTEGRA LIFESCIENCES HOLDINGS CORPORATION AND SUBSIDIARIES
NOTES TO UNAUDITED CONSOLIDATED FINANCIAL STATEMENTS
(UNAUDITED)

8. Segment Reporting

The Company's reportable business segments consist of the Integra NeuroSciences
division, which is a leading provider of implants, instruments and monitors used
in neurosurgery, neurotrauma, and related critical care, and the Integra
LifeSciences division, which develops and manufactures a variety of medical
products and devices, including products based on the Company's proprietary
tissue regeneration technology, which are used to treat soft-tissue and
orthopedic conditions. Integra NeuroSciences sells primarily through a direct
sales organization, and Integra LifeSciences sells primarily through strategic
alliances and distributors. Selected financial information on the Company's
business segments is reported below (in thousands):

<TABLE>
<CAPTION>

Total
Integra Integra Reportable
LifeSciences NeuroSciences Segments Corporate Total
------------- -------------- ----------- ---------- ----------
<S> <C> <C> <C> <C> <C>
First Quarter 2000

Product sales $ 4,479 $ 8,757 $ 13,236 $ -- $ 13,326
Total revenue 5,400 9,007 14,407 -- 14,407
Operating costs 5,216 8,529 13,745 1,912 15,657
Operating income (loss) 184 478 662 (1,912) (1,250)

First Quarter 1999

Product sales $ 4,084 $ 521 $ 4,605 $ -- $ 4,605
Total revenue 4,447 521 4,968 -- 4,968
Operating costs 6,222 773 6,995 1,501 8,496
Operating income (loss) (1,775) (252) (2,027) (1,501) (3,528)
</TABLE>

Included in operating expenses were the following amounts of depreciation and
amortization:

<TABLE>
<CAPTION>

Total
Integra Integra Reportable
LifeSciences NeuroSciences Segments Corporate Total
------------- -------------- ----------- ---------- ----------
<S> <C> <C> <C> <C> <C>
First Quarter 2000 310 711 1,021 61 1,082
First Quarter 1999 371 40 411 32 443
</TABLE>

For the three months ended March 31, 2000 and 1999, the Company's foreign sales,
primarily to Europe and the Asia Pacific regions, were 20% and 18% of total
product sales, respectively.

9. Legal Matters

In July 1996, the Company filed a patent infringement lawsuit in the United
States District Court for the Southern District of California against Merck
KGaA, a German corporation, Scripps Research Institute, a California nonprofit
corporation, and David A. Cheresh, Ph.D., a research scientist with Scripps,
seeking damages and injunctive relief. The complaint charged, among other
things, that the defendant Merck KGaA willfully and deliberately induced, and
continues to willfully and deliberately induce, defendants Scripps Research
Institute and Dr. David A. Cheresh to infringe certain of the Company's patents.
These patents are part of a group of patents granted to The Burnham Institute
and licensed by the Company that are based on the interaction between a family
of cell surface proteins called integrins and the arginine-glycine-aspartic acid
(known as "RGD") peptide sequence found in many extracellular matrix proteins.
The defendants filed a countersuit asking for an award of defendants' reasonable
attorney fees. This case went to trial in February 2000, and on March 17, 2000,
a jury found that Merck KgaA had willfully


9
INTEGRA LIFESCIENCES HOLDINGS CORPORATION AND SUBSIDIARIES
NOTES TO UNAUDITED CONSOLIDATED FINANCIAL STATEMENTS
(UNAUDITED)

9. Legal Matters, continued

induced infringement of the Company's patents and awarded the Company $15.0
million in damages. This award may be adjusted by the court. The Company expects
that Merck KgaA will appeal various decisions of the court and request a new
trial, and it has requested a reduction in damages and a judgment as a matter of
law notwithstanding the verdict. No amounts for this favorable verdict have been
reflected in the Company's financial statements.

Bruce D. Butler, Ph.D., Bruce A. McKinley, Ph.D., and C. Lee Parmley (the "Optex
Claimants"), each parties to a Letter Agreement (the "Letter Agreement") with
Camino NeuroCare, Inc., a wholly-owned subsidiary of the Company ("Camino"),
dated as of December 18, 1996, have alleged that Camino breached the terms of
the Letter Agreement prior to the Company's acquisition of the NeuroCare Group
(Camino's prior parent company). The Letter Agreement contains arbitration
provisions, and the Company and the Optex Claimants have agreed to negotiate
rather than seek arbitration for a limited time. While we believe that Camino
has valid legal and factual defenses, the Optex Claimants have asserted
unspecified significant damages, and we believe that the Optex Claimants are
likely to pursue arbitration under the Letter Agreement if the matter is not
settled otherwise. We cannot predict the outcome of such an arbitration, were it
to take place. In addition, we have asserted a right to indemnification from the
seller of the NeuroCare businesses, but there can be no assurance that
indemnification, if any, will be obtained.

10. Subsequent Events

On April 6, 2000, the Company purchased the Selector(R) Ultrasonic Aspirator,
Ruggles(TM) hand-held neurosurgical instruments and cryosurgery product lines,
including certain assets and liabilities, from NMT Medical, Inc. for $12.0
million in cash. Revenues of the acquired product lines during 1999 were
approximately $12.1 million. This acquisition will be accounted for using the
purchase method of accounting and its results of operations will be included in
the Company's consolidated financial statements as of the date of acquisition.



10
Item 2. Management's Discussion and Analysis of Financial Condition and Results
of Operations

The following discussion should be read in conjunction with the Company's
consolidated financial statements, the notes thereto and the other financial
information included elsewhere in this report and in the Company's 1999 Annual
Report on Form 10-K filed with the Securities and Exchange Commission.

General

The Company develops, manufactures and markets medical devices, implants and
biomaterials. The Company's operations consist of (1) Integra NeuroSciences,
which is a leading provider of implants, instruments, and monitors used in
neurosurgery, neurotrauma, and related critical care and (2) Integra
LifeSciences, which develops and manufactures a variety of medical products and
devices, including products based on our proprietary tissue regeneration
technology which are used to treat soft tissue and orthopedic conditions.
Integra NeuroSciences sells primarily through a direct sales organization, and
Integra LifeSciences sells primarily through strategic alliances and
distributors.

As a result of the acquisitions of the NeuroCare Group of companies
("NeuroCare") in March 1999 and the business, including certain assets and
liabilities, of Clinical Neuro Systems, Inc. ("CNS") in January 2000, and the
transition of all selling and marketing efforts related to INTEGRA(R) Artificial
Skin to Johnson & Johnson Medical ("JJM") under an agreement with JJM (the "JJM
Agreement") in June 1999, the Company's segment financial results for the three
months ended March 31, 2000 and 1999 may not be directly comparable.
Additionally, the financial information discussed below should be considered in
light of the acquisition of certain assets and liabilities from NMT Medical,
Inc. in April 2000.

Results of Operations

Three Months Ended March 31, 2000 Compared to Three Months Ended March 31, 1999

Overall, the Company recorded a net loss of $1.1 million for the three months
ended March 31, 2000, as compared to net income of $0.4 million for the
comparable period in 1999. Included in the 1999 results is a $4.2 million gain
($3.7 million net of taxes) related to the sale of a product line. Operating
results for the three months ended March 31, 2000 improved by $2.2 million, with
an operating loss of $1.3 million recorded in 2000 as compared to a $3.5 million
operating loss in 1999. The improvement in 2000 operating results was primarily
due to the successful integration of recent business acquisitions, including the
$25.4 million NeuroCare acquisition in March 1999 and the $6.8 million
acquisition of CNS in January 2000, the implementation of the JJM Agreement and
the launch of the DuraGen(TM) Dural Graft Matrix product in the third quarter of
1999.

Total revenues increased by $9.4 million to $14.4 million for the three months
ended March 31, 2000 as compared to $5.0 million for the three months ended
March 31, 1999, primarily as a result of business acquisitions. Product sales
increased by $8.6 million to $13.2 million for the three months ended March 31,
2000 as compared to $4.6 million for the three months ended March 31, 1999.
Product sales and cost of product sales were as follows (in thousands):

Integra Integra
NeuroSciences LifeSciences Consolidated
------------- ------------ ------------
Three months ended March 31, 2000:

Product sales................... $ 8,757 $ 4,479 $ 13,236
Cost of product sales........... 4,119 2,473 6,592
Gross margin on product sales... 4,638 2,006 6,644
Gross margin percentage......... 53% 45% 50%


11
Integra          Integra
NeuroSciences LifeSciences Consolidated
------------- ------------ ------------
Three months ended March 31, 1999:

Product sales................... $ 521 $ 4,084 $ 4,605
Cost of product sales........... 298 2,396 2,694
Gross margin on product sales... 223 1,688 1,911
Gross margin percentage......... 43% 41% 41%

Product sales in the Integra NeuroSciences division increased as a result of
acquired product lines and the launch of the DuraGen(TM) product in the third
quarter of 1999. Gross margin on product sales increased to 53% for the three
months ended March 31, 2000, with $95,000 of fair value purchase accounting
adjustments from the CNS acquisition recorded in cost of product sales in the
first quarter of 2000. Gross margin on product sales for the quarter ended March
31, 1999 included the effects of $65,000 of fair value purchase accounting
adjustments recorded in cost of product sales. Excluding purchase accounting
adjustments, gross margin on product sales would have been 54% and 55% in the
first quarter of 2000 and 1999, respectively.

Product sales in the Integra LifeSciences division increased primarily because
of acquired product lines and the first commercial sale of tyrosine
polycarbonate polymers for use in the clinical development of various fixation
devices, all of which were offset by lower sales prices of INTEGRA(R) Artificial
Skin to JJM under the JJM Agreement. Gross margin on product sales increased to
45% for the three months ended March 31, 2000, as compared to 41% for the three
months ended March 31, 1999. Excluding $145,000 of fair value purchase
accounting adjustments recorded in the first quarter of 1999, gross margin on
product sales in 1999 would have been 45%. Lower gross margins on sales of
INTEGRA(R) Artificial Skin to JJM during the three months ended March 31, 2000
and lower utilization of the INTEGRA(R) Artificial Skin manufacturing facility
in the comparable period ended March 31, 1999 resulted in lower overall margins
for the Integra LifeSciences division.

Other revenue in the Integra NeuroSciences segment increased $0.3 million to
$0.3 million for the three months ended March 31, 2000 and consisted of royalty
income. Other revenue in the Integra LifeSciences segment increased to $0.9
million for the three months ended March 31, 2000, as compared to $0.4 million
for the three months ended March 31, 1999. The majority of this increase relates
to contract research funding related to INTEGRA(R) Artificial Skin received
under the JJM Agreement.

Research and development expenses were as follows (in thousands):

Three Months Ended March 31,
2000 1999
----- -----
Integra NeuroSciences $ 491 $ 112
Integra LifeSciences 1,337 1,828
----- -----
Total $1,828 $1,940

Research and development expense in the Integra NeuroSciences segment increased
$0.4 million to $0.5 million for the three months ended March 31, 2000 primarily
due to the NeuroCare acquisition. Research and development activities within the
Integra LifeSciences segment decreased $0.5 million to $1.3 million for the
three months ended March 31, 2000 primarily because of reduced headcount and the
elimination of several research programs that were ongoing in the first quarter
of 1999. The Company has substantially completed the reorganization of its
research and development resources and does not expect further reductions in
research and development expense going forward. Future expenditures will


12
depend upon the progress of ongoing research and development programs, including
those for which the Company receives funding from third parties.

Approximately 41% and 16% of the Company's total research and development
expenses for the three months ended March 31, 2000 and 1999, respectively, were
funded through external grants and development funding programs. The increase in
funded research in 2000 is primarily the result of research funding received
from JJM under the JJM Agreement related to research on INTEGRA(R) Artificial
Skin.

Selling and marketing expenses were as follows (in thousands):

Three Months Ended March 31,
2000 1999
----- -----
Integra NeuroSciences $ 2,417 $ 290
Integra LifeSciences 500 1,270
----- -----
Total $ 2,917 $1,560

Integra NeuroSciences selling and marketing expenses increased by $2.1 million
to $2.4 million for the three months ended March 31, 2000 primarily due to the
NeuroCare and CNS acquisitions. The decrease of $0.8 million in Integra
LifeSciences selling and marketing expenses to $0.5 million for the three months
ended March 31, 2000 is primarily the result of the transition of INTEGRA(R)
Artificial Skin selling and marketing activities to JJM.

General and administrative expenses were as follows (in thousands):

Three Months Ended March 31,
2000 1999
----- -----
Integra NeuroSciences $ 968 $ 55
Integra LifeSciences 789 627
Corporate 1,851 1,469
----- -----
Total $3,608 $2,151

Integra NeuroSciences general and administrative expenses increased to $1.0
million for the three months ended March 31, 2000 primarily due to the NeuroCare
and CNS acquisitions. General and administrative expenses in the Integra
LifeSciences segment increased $0.2 million to $0.8 million for the three months
ended March 31, 2000 primarily due to additional headcount. The increase of $0.4
million in corporate general and administrative expenses to $1.9 million for the
three months ended March 31, 2000 resulted primarily from increased legal fees
associated with the Merck KGaA litigation and additional headcount and facility
costs.

Amortization and other depreciation (excluding $370,000 and $292,000 of
depreciation included in cost of sales for the three months ended March 31, 2000
and 1999, respectively) were as follows (in thousands):

Three Months Ended March 31,
2000 1999
----- -----
Integra NeuroSciences $ 534 $ 18
Integra LifeSciences 117 101
Corporate 61 32
----- -----
Total $ 712 $ 151


13
Amortization and other depreciation in the Integra NeuroSciences segment
increased to $0.5 million for the three months ended March 31, 2000 as a result
of the NeuroCare and CNS acquisitions. Included in this amount is $473,000 of
amortization of goodwill and other intangibles and $61,000 of depreciation.
Amortization and other depreciation in the Integra LifeSciences segment
consisted almost entirely of depreciation.

Interest expense of $280,000 for the three months ended March 31, 2000 consisted
of interest associated with the term loan and revolving credit facility assumed
in the NeuroCare acquisition and interest accrued on the $2.8 million note
payable to the seller of the CNS business.

For the three months ended March 31, 2000 and 1999, the Company recorded a gain
of $115,000 and $4.2 million, respectively, in connection with the sale of a
product line. In the first quarter of 1999, the Company recorded an income tax
provision of $460,000 in connection with the gain on the sale of the product
line.

Liquidity and Capital Resources

The Company has incurred losses from operations since its inception and will
continue to incur such losses unless and until product sales and research and
collaborative arrangements generate sufficient revenue to fund continuing
operations. As of March 31, 2000, the Company had an accumulated deficit of
$95.4 million.

The Company has funded its operations to date primarily through private and
public offerings of equity securities, product revenues, research and
collaboration funding, borrowings under a revolving credit line and cash
acquired in connection with business acquisitions and dispositions. At March 31,
2000, the Company had cash, cash equivalents and short-term investments of
approximately $23.6 million (of which $12.0 million was subsequently used in
April 2000 in the acquisition of certain product lines assets and liabilities
from NMT Medical, Inc.) and $12.3 million in short and long-term borrowings. The
Company's principal uses of funds during the three months ended March 31, 2000
were $4.0 million for the acquisition of CNS, $1.4 million in purchases of
property and equipment and $1.3 million used in operations. During this same
period, the Company raised $5.4 million from the sale of Series C Preferred
Stock and warrants to affiliates of Soros Private Equity Partners LLC and $1.1
million from the issuance of common stock through exercised stock options.

The Company maintains a term loan and the revolving credit facility from Fleet
Capital Corporation (collectively, the "Fleet Credit Facility"), which is
collateralized by all the assets and ownership interests of various subsidiaries
of the Company including Integra NeuroCare LLC, and NeuroCare Holding
Corporation (the parent company of Integra NeuroCare LLC) has guaranteed Integra
NeuroCare LLC's obligations. Integra NeuroCare LLC is subject to various
financial and non-financial covenants under the Fleet Credit Facility, including
significant restrictions on its ability to transfer funds to the Company or the
Company's other subsidiaries. The financial covenants specify minimum levels of
interest and fixed charge coverage and net worth, and also specify maximum
levels of capital expenditures and total indebtedness to operating cash flow,
among others. While the Company anticipates that Integra NeuroCare LLC will be
able to satisfy the requirements of these financial covenants, there can be no
assurance that Integra NeuroCare LLC will generate sufficient earnings before
interest, taxes, depreciation and amortization to meet the requirements of such
covenants. The term loan is subject to mandatory prepayment amounts if certain
levels of cash flow are achieved.


14
Additionally, in January 2000, the Company issued a 5% $2.8 million promissory
note to the seller of the CNS business. The promissory note, which is payable in
two principal payments of $1.4 million each, plus accrued interest, in January
2001 and 2002, is collateralized by inventory, property and equipment of the CNS
business and by a collateral assignment of a $2.8 million promissory note from
one of the Company's subsidiaries.

In the short-term, the Company believes that it has sufficient resources to fund
its operations. However, in the longer-term, there can be no assurance that the
Company will be able to generate sufficient revenues to obtain positive
operating cash flows or profitability.

Other Matters

New Accounting Pronouncements

In June 1998, the Financial Accounting Standards Board issued Statement of
Financial Accounting Standards No. 133 "Accounting for Derivative Investments
and Hedging Activities" ("SFAS No. 133"). SFAS No. 133 establishes accounting
and reporting standards for derivatives and hedging activities and supercedes
several existing standards. SFAS No. 133, as amended by SFAS No. 137, is
effective for all fiscal quarters of fiscal years beginning after June 15, 2000.
The Company does not expect that the adoption of SFAS No. 133 will have a
material impact on the consolidated financial statements.

In December 1999 (as amended in March 2000) the staff of the Securities and
Exchange Commission ("SEC") issued Staff Accounting Bulletin 101, Revenue
Recognition (the "SAB"). To the extent the guidance in the SAB differs from
generally accepted accounting principles previously utilized by an SEC
registrant, the SAB indicates that the SEC staff will not object to reporting
the cumulative effect of a change in accounting principle.

Prior to promulgation of the SAB, the Company had reported some non-refundable,
up-front and milestone fees received pursuant to distribution agreements in the
period earned, which was deemed to be the date when all related material
commitments had been satisfied and no future consideration was required. While
the Company believes the related supply arrangements entered into with its
distributors provides for arms-length pricing of product sales, the SAB requires
that the distribution agreement fees now be linked to the supply arrangements
and reported as additional revenue from product sales made pursuant to those
arrangements. As a result, up-front distribution agreement fees are initially
deferred and subsequently amortized on a straight-line basis over the
contractual period of the supply arrangements.

The Company is currently assessing the full impact that the SAB will have on its
financial statements. Once the final assessment is complete, the total financial
impact of the SAB will be recorded as a cumulative effect of a change in
accounting principle in the second quarter of 2000. The Company currently
anticipates that the cumulative effect as of April 1, 2000 of the change in
accounting principle (if measured at April 1, 2000) would be within a range of
$1.3 million to $3.2 million.



15
PART II.  OTHER INFORMATION

Item 1. Legal Proceedings

In July 1996, the Company filed a patent infringement lawsuit in the United
States District Court for the Southern District of California against Merck
KGaA, a German corporation, Scripps Research Institute, a California nonprofit
corporation, and David A. Cheresh, Ph.D., a research scientist with Scripps,
seeking damages and injunctive relief. The complaint charged, among other
things, that the defendant Merck KGaA willfully and deliberately induced, and
continues to willfully and deliberately induce, defendants Scripps Research
Institute and Dr. David A. Cheresh to infringe certain of the Company's patents.
These patents are part of a group of patents granted to The Burnham Institute
and licensed by the Company that are based on the interaction between a family
of cell surface proteins called integrins and the arginine-glycine-aspartic acid
(known as "RGD") peptide sequence found in many extracellular matrix proteins.
The defendants filed a countersuit asking for an award of defendants' reasonable
attorney fees. This case went to trial in February 2000, and on March 17, 2000,
a jury found that Merck KgaA had willfully induced infringement of the Company's
patents and awarded the Company $15.0 million in damages. This award may be
adjusted by the court. The Company expects that Merck KgaA will appeal various
decisions of the court and request a new trial, and it has requested a reduction
in damages and a judgment as a matter of law notwithstanding the verdict. No
amounts for this favorable verdict have been reflected in the Company's
financial statements.

Item 2. Changes in Securities and Use of Proceeds

On March 29, 2000, the Company issued and sold to affiliates of Soros
Private Equity Partners LLC 54,000 shares of Series C Convertible Preferred
Stock and warrants to purchase 300,000 shares of common stock of the Company at
an exercise price of $9.00 per share. The aggregate purchase paid by the
purchasers was $5.4 million. The shares of Series C Preferred Stock are
currently convertible into 600,000 shares of common stock of the Company. The
foregoing securities were issued by the Company in reliance upon Section 4(2) of
the Securities Act of 1933, as amended, and Rule 506 thereunder.

Item 6. Exhibits and Reports on Form 8-K

(a) Exhibits

Exhibit
Number Description of Exhibit
- ------ ----------------------
2.1 Asset Purchase Agreement, dated as of January 14, 2000,
among Clinical Neuro Systems Holdings LLC, Clinical Neuro
Systems, Inc., Surgical Sales Corporation (trading as
Connell Neurosurgical) and George J. Connell.

2.2 Asset Purchase Agreement dated March 20, 2000 by and among
Integra Selector Corporation, NMT Neurosciences (US), Inc.
and NMT Medical, Inc.

2.3 Purchase Agreement dated March 20, 2000 by and among NMT
Medical, Inc., NMT Neurosciences (US), Inc., NMT Neurosciences
Holdings (UK) Ltd., NMT Neurosciences (UK) Ltd., Spembly
Medical Ltd., Spembly Cryosurgery Ltd., Swedemed AB, Integra
Neurosciences Holdings (UK) Ltd. and Integra Selector
Corporation.

4.1 Certificate of Designation, Rights and Preferences of Series C
Convertible Preferred Stock of Integra LifeSciences Holdings
Corporation dated March 21, 2000.


16
4.2           Certificate of Amendment of Certificate of
Designation, Rights and Preferences of Series B
Convertible Preferred Stock of Integra LifeSciences
Holdings Corporation dated March 21, 2000.

4.3 Warrant to Purchase 270,550 Shares of Common Stock of Integra
LifeSciences Holdings Corporation issued to Quantum Industrial
Partners LDC.

4.4 Warrant to Purchase 29,450 Shares of Common Stock of Integra
LifeSciences Holdings Corporation issued to SFM Domestic
Investments LLC.

10.1 Secured Promissory Note, dated January 14, 2000, from
Clinical Neuro Systems Holdings LLC to Clinical Neuro
Systems, Inc.

10.2 Security Agreement, dated as of January 14, 2000, among
Clinical Neuro Systems Holdings LLC, Clinical Neuro Systems,
Inc. and George J. Connell.

10.3 Collateral Assignment, dated as of January 14, 2000, from
Clinical Neuro Systems Holdings LLC to Clinical Neuro
Systems, Inc. and George J. Connell.

10.4 Subordinated Promissory Note, dated January 14, 2000, from
Integra LifeSciences Corporation to Clinical Neuro Systems
Holdings LLC.

10.5 Consulting Agreement, dated January 14, 2000, between
Integra LifeSciences Corporation and George J. Connell

10.6 Series C Convertible Preferred Stock and Warrant Purchase
Agreement dated February 16, 2000 among Integra LifeSciences
Holdings Corporation, Quantum Industrial Partners LDC and SFM
Domestic Investments LLC.

10.7 Amended and Restated Registration Rights Agreement dated
March 29, 2000 among Integra LifeSciences Holdings
Corporation, Quantum Industrial Partners LDC and SFM
Domestic Investments LLC.

10.8 Employment Agreement between Michael D. Pierschbacher and
the Company dated December 31, 1998.

10.9 Employment Agreement between Donald R. Nociolo and the
Company dated December 31, 1998.

27 Financial Data Schedule

(b) Reports on Form 8-K

The Company filed with the Securities and Exchange Commission a Report on Form
8-K dated January 14, 2000 with respect to the Company's acquisition of the
business, including certain assets and liabilities, of Clinical Neuro Systems,
Inc.

The Company filed with the Securities and Exchange Commission a Report on Form
8-K dated March 20, 2000 with respect to (i) the verdict reached in the case
Integra LifeSciences (and certain affiliates) and The Burnham Institute vs.
Merck KGaA and (ii) the announcement of the Company's agreement to acquire
certain assets and liabilities from NMT Medical, Inc.






17
SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its behalf
by the undersigned thereunto duly authorized.

INTEGRA LIFESCIENCES HOLDINGS CORPORATION

Date: May 12, 2000 /s/ Stuart M. Essig
--------------------
Stuart M. Essig
President and Chief Executive Officer




Date: May 12,2000 /s/ David B. Holtz
-------------------

David B. Holtz
Vice President, Finance and Treasurer


18
INDEX OF EXHIBITS

<TABLE>
<CAPTION>

Exhibit
Number Description of Exhibit Location
- ------ ---------------------- --------

<S> <C> <C>
2.1 Asset Purchase Agreement, dated as of January 14, 2000, (Exh. 2)
among Clinical Neuro Systems Holdings LLC, Clinical Neuro
Systems, Inc., Surgical Sales Corporation (trading as
Connell Neurosurgical) and George J. Connell. (1)

2.2 Asset Purchase Agreement dated March 20, 2000 by and among (Exh. 2.1)
Integra Selector Corporation, NMT Neurosciences (US), Inc.
and NMT Medical, Inc. (2)

2.3 Purchase Agreement dated March 20, 2000 by and among NMT (Exh. 2.2)
Medical, Inc., NMT Neurosciences (US), Inc., NMT Neurosciences
Holdings (UK) Ltd., NMT Neurosciences (UK) Ltd., Spembly
Medical Ltd., Spembly Cryosurgery Ltd., Swedemed AB, Integra
Neurosciences Holdings (UK) Ltd. and Integra Selector
Corporation.(2)

4.1 Certificate of Designation, Rights and Preferences of Series C (Exh. 4.1)
Convertible Preferred Stock of Integra LifeSciences Holdings
Corporation dated March 21, 2000. (3)

4.2 Certificate of Amendment of Certificate of Designation, Rights and (Exh. 4.2)
Preferences of Series B Convertible Preferred Stock of Integra
LifeSciences Holdings Corporation dated March 21, 2000. (3)

4.3 Warrant to Purchase 270,550 Shares of Common Stock of Integra (Exh. 4.3)
LifeSciences Holdings Corporation issued to Quantum Industrial
Partners LDC. (3)

4.4 Warrant to Purchase 29,450 Shares of Common Stock of Integra (Exh. 4.4)
LifeSciences Holdings Corporation issued to SFM Domestic
Investments LLC. (3)

10.1 Secured Promissory Note, dated January 14, 2000, from (Exh. 10.1)
Clinical Neuro Systems Holdings LLC to Clinical Neuro
Systems, Inc. (1)

10.2 Security Agreement, dated as of January 14, 2000, among (Exh. 10.2)
Clinical Neuro Systems Holdings LLC, Clinical Neuro Systems,
Inc. and George J. Connell. (1)

10.3 Collateral Assignment, dated as of January 14, 2000, from (Exh. 10.3)
Clinical Neuro Systems Holdings LLC to Clinical Neuro
Systems, Inc. and George J. Connell. (1)

10.4 Subordinated Promissory Note, dated January 14, 2000, from (Exh. 10.4)
Integra LifeSciences Corporation to Clinical Neuro Systems
Holdings LLC. (1)

10.5 Consulting Agreement, dated January 14, 2000, between (Exh. 10.5)
Integra LifeSciences Corporation and George J. Connell (1)

10.6 Series C Convertible Preferred Stock and Warrant Purchase (Exh. 10.1)
Agreement dated February 16, 2000 among Integra LifeSciences
Holdings Corporation, Quantum Industrial Partners LDC and SFM
Domestic Investments LLC. (3)
</TABLE>


19
<TABLE>
<CAPTION>


<S> <C> <C>
10.7 Amended and Restated Registration Rights Agreement dated (Exh. 10.2)
March 29, 2000 among Integra LifeSciences Holdings
Corporation, Quantum Industrial Partners LDC and SFM
Domestic Investments LLC. (3)

10.8 Employment Agreement between Michael D. Pierschbacher and
the Company dated December 31, 1998. (4)

10.9 Employment Agreement between Donald R. Nociolo and the
Company dated December 31, 1998. (4)

27 Financial Data Schedule (4)
</TABLE>


(1) Incorporated by reference to the indicated exhibit to the Company's
Report on Form 8-K filed with the Commission on January 27, 2000.
(2) Incorporated by reference to the indicated exhibit to the Company's
Report on Form 8-K filed with the Commission on March 28, 2000.
(3) Incorporated by reference to the indicated exhibit to the Company's
Report on Form 8-K filed with the Commission on April 10, 2000.
(4) Filed herewith.





20