As of December 2025 Spyre Therapeutics has a market cap of C$3.59 Billion. This makes Spyre Therapeutics the world's 4200th most valuable company by market cap according to our data. The market capitalization, commonly called market cap, is the total market value of a publicly traded company's outstanding shares and is commonly used to measure how much a company is worth.
On Dec 14th, 2025 the market cap of Spyre Therapeutics was reported to be: